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Most common adverse events at all doses: Nausea (15-30%, dose-related) Vomiting (5-15%) Decreased appetite (~20%) Constipation (5-12%) Cagrilintide-specific notes: A 2025 Bayesian network meta-analysis of incretin-based therapies reported cagrilintide had one of the lowest GI odds ratios across the studied compound class
Inui et al
How GLP-1 Lowers Inflammation in the Body Although originally approved for diabetes, researchers discovered something important: GLP-1 medications consistently reduce inflammation in fat tissue, the gut, the blood vessels, and even the immune system
In addition, multi-acting unimolecular peptides have emerged as highly promising therapeutics in obesity and T2D, typified by the GIP/GLP-1 hybrid peptide tirzepatide
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